Literature summary extracted from

Johne, J.; Blume, C.; Benz, P.M.; Pozgajova, M.; Ullrich, M.; Schuh, K.; Nieswandt, B.; Walter, U.; Renne, T.
Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma (2006), Biol. Chem., 387, 173-178.

Application

EC Number	Application	Comment	Organism
3.4.21.38	medicine	limited activation of factor XIIa is sufficient to promote plasma kallikrein activation, resulting in the conversion of high-molecular-weight kininogen and in bradykinin generation. Presence of platelets significantly promotes factor XIIa-initiated bradykinin formation and critically promotes factor XIIa-driven thrombin and fibrin formation	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.38	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.38	blood	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
3.4.21.38	additional information	-	limited activation of factor XIIa is sufficient to promote plasma kallikrein activation	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)